Non-Hodgkins lymphoma is the name of a group of neoplasmas that mainly arise from deviating B cell lymphocytes. The locations and manifestations can diverge greatly, which hampers attaining a short review of these afflictions. Non-Hodgkins lymphoma is relatively frequent in industrial countries and affects mainly the elderly. The incidence is on the increase but concurrently there is progress in diagnostics and therapy. Immune typing of the cancer cells and detection of certain serum proteins provides a sharper classification, as well as more adequate therapeutic schemes and prognostication. The classic spectre of mainly chemotherapy, and sometimes radiation therapy or surgery has been extended with immune therapy and autologous bone marrow re-infusion. Despite an ongoing shift to more severe forms the survival chances stay on the increase.