The fracture strength of endodontically treated molars restored by means of various types of direct and indirect materials was studied in vitro. 105 sound molars were endodontically treated and randomly assigned to 1 control group (endodontic access cavity only) and 6 experimental groups (n = 15) with restorations of the following materials: glass fibre reinforced composite (GFRC); microhybrid composite (C); microhybrid composite restoration with glass fiber post (CP); full-contour lithium disilicate crown (LDS); full-contour lithium disilicate crown with glass fiber post (P-LDS); and an endocrown (EC). Specimens were thermo-mechanically aged and axially loaded until failure. Data were analysed using ANOVA and Tukey’s post hoc test (α = 0.05). Fracture strength was significantly affected by the type of restoration (p = 0.000). LDS had significantly higher fracture strength than the control group and GFRC, C and CP groups. Groups EC, LDS and P-LDS were not statistically different from each other in fracture strength. This was also the case with EC, P-LDS and all composite groups. The glass fibre strength of composite restoration resulted in significantly fewer fatal fractures.