An 18-year-old boy was referred because of diminished chewing capacity. In addition he had aesthetic concerns about his appearance. From the age of 4, he had been known to suffer from cherubism, a rare hereditary, self-limiting fibrous dysplasia characterised by painless enlargement of the jaws. The characteristic ‘angel-like eyes-to-heaven’ appearance was only minimally visible because the maxilla was hardly affected. Radiographs showed well-defined multilocular radiolucencies and with age, thick sclerotic borders were visible. These intracortical sources caused compression of the dentition, which resulted in malocclusive and abnormal dentition. In the mandible only the teeth 35, 36 and 46 were present. To restore the dentition, orthodontic treatment and instalment of endosseous implants were planned. In advance, the mandible was explored, and the granulomas were removed and replaced by autologous bone transplants. After orthodontic treatment 5 Brånemark implants were successfully installed to support an overdenture.