Head and neck tumours possess several mechanisms to hinder an appropriate immune response against the tumour cell. In the first place, the tumour cells attempt to suppress the presentation of tumour-associated antigens to the cells of the immune system. Tumours also have a negative effect on the surface structures of the efferent blood vessel epithelium, thereby inhibiting the recruitment of immune cells. In addition, proteins are secreted capable of inactivating immune cells. These immunosuppressive activities of the tumour result in a deterioration of life expectancy. Several experimental methods to improve the immune response of the patient against tumour cells are currently being explored.
|Publicatiedatum||8 maart 2013|
|Editie||Ned Tijdschr Tandheelkd - Jaargang 120 - editie 3 - maart 2013; 143-146|